urb597 is a Alkali product. Key specs — Origin: China (Mainland).
Product Description
URB597 (CAS 546141-08-6)
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| Formal Name | (3'-​(aminocarbonyl)[1,​1'-​biphenyl]-​3-​yl)-​cyclohexylcarbamate |
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| CAS Number | 546141-08-6 |
| Molecular Formula | C20H22N2O3 |
| Formula Weight | 338.4 |
| Formulation | A crystalline solid |
| Purity | >98% |
| Stability | 2 years |
| Storage | -20°C |
| Shipping | WET ICEin continental US; may vary elsewhere |
| SMILES | O=C(NC1CCCCC1)​Oc1cccc(c1)​c1cccc(c1)​C(=O)​N |
Description
The enzyme fatty acid amide hydrolase (FAAH) is widely expressed in brain and other tissues, and is capable of hydrolyzing anandamide (AEA) and other simple esters and amides with long unsaturated acyl chains. URB597 was recently synthesized and reported to be a potent and selective inhibitor of FAAH. URB597 inhibits FAAH with an IC50 of 4.6 nM in brain membranes and 0.5 nM in intact neurons. It has been demonstrated in FAAH(-/-) mice that marked depression of FAAH activity results in reduced sensation of pain and enhanced endocannabinoid signalling. URB597 exhibits both anti-nociceptive and anxiolytic effects in vivo without evoking other symptoms associated with cannabinoid-like compounds. Thus, URB597 may serve as a lead compound for the development of new analgesic and anxiolytic drugs.1Cravatt, B.F., Giang, D.K., Mayfield, S.P., et al. Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature38483-87(1996).
2Kathuria, S., Gaetani, S., Fegley, D., et al. Modulation of anxiety through blockade of anandamide hydrolysis. Nat Med1(9)76-81(2003).
3Cravatt, B.F., Demarest, K., Patricelli, M.P., et al. Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase. Proc Natl Acad Sci USA98(16)9371-9376(2001).
Background Reading
Cravatt, B.F., Giang, D.K., Mayfield, S.P., et al. Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature38483-87(1996).
Kathuria, S., Gaetani, S., Fegley, D., et al. Modulation of anxiety through blockade of anandamide hydrolysis. Nat Med1(9)76-81(2003).
Cravatt, B.F., Demarest, K., Patricelli, M.P., et al. Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase. Proc Natl Acad Sci USA98(16)9371-9376(2001).
