camptothecin

Detailed Selling Lead Description

Camptothecin is a plant secondary metabolite used as an anti-cancer drug that damages DNA, leading to the destruction of the comes from Camptotheca acuminata, a deciduous tree found in southern China. A close analogue, 9-methoxycamptothecin, is also present in the same source.

Mechanism of action

Camptothecin affects the activity of the enzyme topoisomerase I, whose normal action is to cleave, unwind, and religate DNA. When camptothecin binds to topoisomerase I, it will be able to cleave but not to religate DNA. Thereby, camptothecin causes single strand breaks in DNA

Description

Brown crystalline powder; easy to loss activity under light.

CAS#:7689-03-4

Molecular formula: C20H16N2O4

Molecular weight: 348.36

Quality standard

(1) Specific optical rotation : +3132°

(2)Melting point: 264267

(3)Purity: 9899%(HPLC)

(4)Loss on dry:<0.5%

(5)Ash: <1%

(6) Heavy metals : <10ppm

(7)Arsenic salt:<1ppm
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