Trilostane

Trilostane Synonyms: (2-alpha,4-alpha,5-alpha,17-beta)-4,5-epoxy-17-hydroxy-3-oxoandrostane-2-car;17-beta)-ph;4-alpha,5-epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril;4-alpha,5-epoxy-3,17-dihydroxy-5-alpha-androst-2-ene-2-carbonitrile;4-alpha-5-epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril CAS: 13647-35-3 MF: C20H27NO3 MW: 329.43 EINECS: 237-133-0 Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Inhibitor Chemical Properties: Tan Crystals Usage: An inhibitor of steroid biosynthesis.

Used as an adrenocortical suppressant. Used in the treatment of breast cancer . antifungal, inhibits mitosis in metaphase . Packing:1kg/foil bag or as required

Trilostane is an inhibitor of isoforms 3β-HSD and 3β-HSD2 of the enzyme 3β-hydroxysteroid dehydrogenase, which plays a role in adrenal steroid biosynthesis. Investigators believe that Arg195 in 3β-HSD versus Pro195 in 3β-HSD2 attributes to the competitive inhibition of 3β-HSD, but not 3β-HSD2 by Trilostane.

Research shows that trilostane is effective in suppressing the intracellular production oin LNCaP-FGC prostate cancer cells and inhibiting cortisol biosynthesis in the human adrenal gland. This product serves as a useful tool in steroid biosynthesis research.

Test Items Specification Test Results Appearance white oralmost white,crystalline powder Conform Solubility Freely soluble in water,practically insoluble or very slightly soluble in alcohol and in methylene chloride.

Conform Identification A The UV absorption spectrum of the sample shows an absorption maximum at 276nm.The specific absorbance at the Maximum is55 to 64. Conform B Infraed absorption spectrophotometry.

Conform C Chromatogram obtained with test solution (b) is similar in position color & size to the principal spot in the chromatogram obtained with the reference solution. Conform D An orange-red color develop in methylene chloride layer. Conform E It geves reaction (a) of sulphates.

Conform Appearance of solution Solution S is clear and not more intensely coloured than reference solution in BY6. Conform Optical rotation negative 0.10° to +0.10°determined on solution S. +0.01° Acidity or alkalinity NMT 0.4ml of 0.01M HCL is required to change the color of the indicator to red.

Conform Related substances Impurity J ≤0.20% Conform Any other impurity ≤0.30% Conform Total impurity ≤1.0% Conform Boron ≤50ppm Conform Sulphated ash ≤0.10% 0.06% Loss on drying ≤0.5% 0.30% Assay(on dried basis) 98.0~101.0% 99.5% Conclusion The test results above BP2009