Spironolactone Diuretic Powder Pharmaceutical Intermediate Aldactone , Antisterone

1. Overview

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It is a synthetic, steroidal antimineralocorticoid and antiandrogen that also has some weak progestogen properties, as well as some indirect estrogen and glucocorticoid effects. It is used primarily as a diuretic and antihypertensive, but may also be employed for the purpose of reducing elevated or unwanted androgen activity in the body.It acts predominantly as an antagonist of the mineralocorticoid (or aldosterone) and androgen receptors, and in relation to its antimineralocorticoid effects, belongs to a class of pharmaceutical drugs known as potassium-sparing diuretics.

2. Applications

Spironolactone is competitive inhibition of aldosterone drugs, drug itself is not active, role is diuresis and endogenous competitive aldosterone antagonist and happen, belongs to the potassium diuretics.

3. Specifications

Test Items Specification Test Results

Appearance Almost white crystalline powder Almost white crystalline powder

Identification Meet the requirements Meet the requirements

Melting range 198℃~209℃

Between 198℃ and 209℃ 205.0℃~207.0℃

Specific rotation -33°~-37°

Between -33° and -37° -35°

Loss on drying ≤0.5%

Not more than 0.5% 0.2%

Limit of mercapto compounds Meet the requirements Meet the requirements

Ordinary impurities Meet the requirements Meet the requirements

Organic volatile impurities Meet the requirements Meet the requirements

Assay(on the dried basis) 97.0%~103.0%(C24H32O4S)

Between 97.0% and 103.0% 98.99%

Conclusion Meet the requirements of USP29