SelenoExcell® High Selenium Supplement

Introduction SelenoExcell® High Selenium Yeast raw material is a high-potency (1,200 mcg/g), 100% organically-bound selenium yeast powder ingredient. As a natural nutritional food source, yeast replicates the mineral conversion process performed by most plants (i.e. garlic, broccoli).

This natural plant process converts inorganic (low bioavailability, potentially toxic) minerals to safer organic (high bioavailability) forms for improved nutrient utilization.

SelenoExcell® is a top quality selenium yeast powdered ingredient supported by a Clinical Trial Agreement with the Cancer Prevention Division of the National Cancer Institute and also selected by leading research teams for a series of health and cancer related studies based on its organic certification and strictly controlled quality as demonstrated by its minimal batch-to-batch variation.

Benefits • Starts with a primary grown, pure culture yeast strain. • Natural powder raw material of selenium in 100% organically bound form • Provides a wide variety of selenium compounds including amino acid complexed, lipids and cellular by-layers in a uniform powder. • Controlled to provide minimal batch-to-batch variation as a natural ingredient powder. • Selected by leading cancer and health research groups as an approved raw material. • Uniform size and shaped particles meeting stringent ingredient mesh requirements. • Recently received independent GRAS (Generally Recognized as Safe) approval. • Superior Quality Specifications for a Selenium Yeast raw material powder.

Advantages SelenoExcell® High Selenium Yeast has been selected as the intervention agent ingredient in a series of cancer and health related studies. The product has gained the confidence of researchers, government-funded organizations and numerous privately funded health organizations.

These collective research efforts in investigating the positive health benefits of selenium will assist in raising public awareness of selenium supplementation.

Applications SelenoExcell® high Selenium Yeast raw material powder functions well when utilizing most production methods employed by nutraceutical companies.

Whether producing capsules, tablets, hard gels or soft gels, the spray-dried powder form of SelenoExcell® high Selenium Yeast ingredient provides the finished product manufacturer an ideal selenium yeast raw material.

As a result of the recent GRAS (Generally Recognized as Safe) approval and classification, SelenoExcell® high selenium yeast may now be added to many foods and beverages.

Antioxidant Enzyme In 1973, Dr. J.T. Rotruck of the University of Wisconsin and his colleagues discovered that selenium is a component of glutathione peroxidase, an antioxidant enzyme produced in the human body. This resulted in selenium’s essential-nutrient status.

Selenium is not an antioxidant in the classical sense, but is an essential component of endogenous antioxidant enzymes, such as glutathione peroxidases. Glutathione peroxidases are the most studied selenium-containing antioxidant enzymes.

These antioxidants protect the water-containing structures in the body, particularly the cell interiors, but also outside the cells and within the bloodstream. Glutathione peroxidases protect cells against damage by halting free-radical chain reactions involving lipid peroxides (rancid fats) and hydroperoxides (oxidized chemicals).

They do this by using glutathione as a hydrogen donor, which neutralizes the free radical by restoring electron balance. Selenium also indirectly protects cell membranes and lipoproteins (the lipid-containing parts of the body).

Although selenium-containing enzymes are not stored in the bi-layered cell membranes, they do act on both the interior side of the cell membranes and the extracellular surfaces of the cell membranes and lipoproteins, thus protecting these areas from inside and outside of the cell.

SelenoExcell® Independently Certified GRAS Cypress Systems has independently self-certified its SelenoExcell® High Selenium Yeast raw material as GRAS (Generally Recognized As Safe) for use in several food categories. The determination was based on scientific protocols including the safety assessment criteria established by the U.S. Food and Drug Administration.

Distribution Worldwide by Garuda International Cypress Systems, Inc., the manufacturer of SelenoExcell® High Selenium Yeast raw material powder has entered a world-wide strategic distribution agreement with The two companies have joined forces to serve the dietary supplement, functional food and specialty nutrition markets with the complete line of the Cypress powdered yeast-based mineral ingredients.

Cinical Trials Clinical Trial Agreement (CTA) Cypress Systems, the manufacturer of SelenoExcell® high Selenium Yeast raw material has signed a Clinical Trial Agreement (CTA) with the National Cancer Institute’s Division on Cancer Prevention (DCP).

The agreement is to promote the use of SelenoExcell® High Selenium Yeast ingredient in clinical trials that my lead to a New Drug Application (NDA) and a Biological License Application (BLA).

The NDA and BLA are vehicles by which natural products like SelenoExcell® are made widely available to cancer patients and the general public as cancer prevention and control therapies.

Nutritional Prevention of Cancer Trial (Extended) The original Nutritional Prevention of Cancer Trial was extended for 3 years and supported by renewed funding of $2,500,000 from the National Cancer Institute. Following the unblinding of the original study group, the remaining participants have been placed on selenium supplementation.

The selected intervention agent and source of organically bound selenium is SelenoExcell® High Selenium Yeast.

Nutritional Prevention of Cancer Trial was published in The Journal of the American Medical Association, Vol. 276 No. 24: 1957 - 1963, 1996 and the British Journal of Urology, Vol. 81: 730 - 734, 1998.

Funding Organizations • National Cancer Institute (NCI) U.S.A and Canada • National Institute of Health (NIH) United States of America • U.S. Department of Agriculture (USDA) • U.S. Department of Defense (DOD) • International Cancer Alliances

The Gold Standard • Randomized Controlled Clinical Trial • Double Blinded • Placebo Controlled • Primary and Secondary End Points • Long Term Studies • Peer Reviewed • Journal Publication