Ropivacaine hydrochloride

Ropivacaine hydrochloride   Synonyms: S-ROPIVACAINE HCL;(S)-ROPIVACAINE HYDROCHLORIDE;ROPIVACAINE HYDROCHLORIDE MONOHYDRATE;ROPIVCACAINE HYDROCHLORIDE;ROPIVACAINE HCL;(S)-1-propyl-2',6'-dimethylanilinoformoxylpiperidine monohydrochloride monohydrate;(S)-1-propyl-2',6'-dimethylanilinoformoxylpiperidine,monohydrochloride,monohydrate;(S)-Ropivaxaine hydrochloride  CAS: 132112-35-7  MF: C17H26N2O.ClH.H2O  MW: 328.88    Chemical Properties : White Solid 

Specification:

Product name: Ropivacaine hydrochloride Other Name ROPIVCACAINE HYDROCHLORIDE;ROPIVACAINE HCL;(S)-ROPIVACAINE HYDROCHLORIDE;S-ROPIVACAINE HCL;n-(2,6-dimethylphenyl)-1-propyl-piperidine-2-carboxamide hydrochloride;Ropivacaine mesilate;Ropivacaine hydrochloride;(2S)-N-(2,6-dimethylphenyl)-1-propyl-pipecolinamide hydrochloride Original China CAS 132112-35-7  Molecular formula C17H26N2O.ClH.H2O  Molecular Weight 328.88  Brand name NJBNSteroid Delivery time within 24 hours upon receipt of payment Delivery Fast and secure shipping by EMS, DHL, TNT, FedEx, UPS Purity 99% Package Discreet and Hidden package according to specific requirement Appearance White powder Certification SGS, ISO 9001, KOSHER Payment Terms Western Union, Money Gram , T/T, Bitcoin Minimum Order Quantity 10g Price Negotiable Usage It is used for pain control MF

Description Ropivacaine is a local anaesthetic drug belonging to the amino amide group. The name ropivacaine refers to both the racemate and the marketed S-enantiomer. Ropivacaine hydrochloride is commonly marketed by AstraZeneca under the trade name Naropin.

Medical Uses Ropivacaine is indicated for local anaesthesia including infiltration, nerve block, epidural and intrathecal anaesthesia in adults and children over 12 years. It is also indicated for peripheral nerve block and caudal epidural in children 1–12 years for surgical pain.

It is also sometimes used for infiltration anaesthesia for surgical pain in children. Ropivacaine is often coadministered with fentanyl for epidural analgesia, for example in pregnant women during labour.

Adverse effect

Adverse drug reactions (ADRs) are rare when it is administered correctly. Most ADRs relate to administration technique (resulting in systemic exposure) or pharmacological effects of anesthesia, however allergic reactions can rarely occur.

Systemic exposure to excessive quantities of ropivacaine mainly result in central nervous system (CNS) and cardiovascular effects – CNS effects usually occur at lower blood plasma concentrations and additional cardiovascular effects present at higher concentrations, though cardiovascular collapse may also occur with low concentrations.

CNS effects may include CNS excitation (nervousness, tingling around the mouth, tinnitus, tremor, dizziness, blurred vision, seizures followed by depression (drowsiness, loss of consciousness), respiratory depression and apnea).

Cardiovascular effects include hypotension, bradycardia, arrhythmias, and/or cardiac arrest – some of which may be due to hypoxemia secondary to respiratory depression.

Specification :  

  Product name  Bupivacaine hydrochloride CAS No  14252-80-3 EINECS No  241-917-8  MF  C18H31ClN2O2  MW  342.9  Appearance  White crystal powder  Purity  98.5%~101.5%  Ash  0.1% max  Loss on dry  0.1% max  Heavy Metal  10ppm max  Package  5/10kg cardboard drum  Standard  USP 30

 Use method At 25°C ropivacaine HCl has a solubility of 53.8 mg/mL in water, a distribution ratio between n-octanol and phosphate buffer at pH 7.4 of 14:1 and a pKa of 8.07 in 0.1 M KCl solution. The pKa of ropivacaine is approximately the same as bupivacaine (8.1) and is similar to that of mepivacaine (7.7).

However, ropivacaine has an intermediate degree of lipid solubility compared to bupivacaine and mepivacaine. Naropin (ropivacaine hcl) Injection is preservative-free and is available in single dose containers in 2 (0.2%), 5 (0.5%), 7.5 (0.75%) and 10 mg/mL (1%) concentrations.

The specific gravity of Naropin (ropivacaine hcl) Injection solutions range from 1.002 to 1.005 at 25℃.