Rimonabant hydrochloride

Quick Detail: Rimonabant hydrochloride Alias: RIMONABANT HCl; Rimonabant(Acomplia) CAS: 158681-13-1 Molecular Formula.: C22H21Cl3N4O.

ClH Molecular Weight.: 500.25 Appearances: White or off white solid Usage: Pharmaceutical intermediates, fine organic synthesis and catalyst Description: Rimonabant hydrochloride (SR-141716A) is a potent and selective CB1 inverse agonist/antagonist with a Ki of 1.6 nM, minimal affinity for CB2, and and some GPR55 agonist activity.

Rimonabant was developed as an anti-obesity drug because of its appetite suppressant activity, but was taken off the market because of side effects of depression and anxiety. Under development by Sanofi-Aventis, Acomplia (rimonabant) is a selective CB1 endocannabinoid receptor antagonist indicated for the treatment of obesity.

It works by blocking endogenous binding to neuronal CB1 receptors. Activation of these receptors by endoegenous cannabinoids, such as anadamide, increases appetite. It is the most advanced endocannabinoid receptor antagonist in clinical development and offers a novel therapeutic approach to appetite control and weight reduction.