Recombinant Human Protocadherin alpha-3(PCDHA3)

Product Name: Recombinant Human Protocadherin alpha-3(PCDHA3) Product Type : Recombinant Protein Code : CSB-YP896908HU >> Yeast CSB-EP896908HU >> E.coli CSB-BP896908HU >> Baculovirus CSB-MP896908HU >> Mammalian cell Size : 1mg Uniprot NO. : Q9Y5H8 Abbreviation : PCDHA3 Storage : Store at -20℃, for extended storage, conserve at -20℃ or -80℃.

Storage Buffer : Tris-based buffer,50% glycerol Species : Human Purity : >90% ( SDS-PAGE )

Gene Names : Name:PCDHA3 Protein Names : Recommended name: Protocadherin alpha-3 Short name= PCDH-alpha-3 Expression Region : 30-697 Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.

Product Info : His tagged Protein Description : Extracellular domain Target details : This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters.

The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster.

The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain.

Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.