Rat Androgen receptor(AR) ELISA kit

Product Name

Rat Androgen receptor(AR) ELISA kit

Product Type : ELISA Kit

Code : CSB-EL001975RA

Size : 96T,5×96T,10×96T

Uniprot NO. : P15207

Abbreviation : AR

Protein Biological Process 1 : Transcription/Transcription regulation

Alias : RP11-383C12.1, AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM, dihydrotestosterone receptor

Species : Rat

Protein Biological Process 3 : Transcription

Sample Types : serum, plasma, tissue homogenates, cell lysates

Detect Range : 23.5 pg/ml-1500 pg/ml

Sensitivity : 5.8 pg/ml

Assay Time : 1-5h

Sample Volume : 50-100ul

Detection Wavelengt : 450 nm

Availability : 5-7 working days

Research Area : Cancer

Protocol

CSB-EL001975RA

Protocol may be improved. Please feel free to contact CUSABIO product specialist to obtain the latest version.

Target details : The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.