Promethazine hydrochloride

Promethazine hydrochloride

Promethazine HCl Product Name: Promethazine hydrochloride Promethazine HCl CAS: 58-33-3 Promethazine HCl MF: C17H21ClN2S Promethazine HCl MW: 320.88 Promethazine HCl EINECS: 200-375-2 Promethazine HCl MP: 230-232 °C Promethazine HCl Storage: Temp. Refrigerator Promethazine HCl Merck: 13, 7878 Promethazine HCl Apperance: White Solid Promethazine HCl Usage: Antihistaminic, antiemetic, CNS depressant; Stool softener

Specification: Product name: Promethazine hydrochloride Other Name 10-(2-dimethylamino-1-propyl)phenothiazine hydrochloride;PROMETHAZINE HCL;PROMETHAZINE HYDROCHLORIDE;PHENERGAN;10-(2-(dimethylamino)propyl)phenothiazinemonohydrochloride;10-(2-(dimethylamino)propyl)-phenothiazinmonohydrochloride;10-(2-dimethylaminopropyl)phenothiazinehydrochloride;10-(3-dimethylaminoisopropyl)phenothiazinehydrochloride Original China CAS 58-33-3 Molecular formula C17H21ClN2S EINECS 200-375-2 Molecular Weight 320.88 Brand name NJBNSteroid Delivery time within 24 hours upon receipt of payment Delivery Fast and secure shipping by EMS, DHL, TNT, FedEx, UPS Purity 99% Package Discreet and Hidden package according to specific requirement Appearance White powder Certification SGS, ISO 9001, KOSHER Payment Terms Western Union, Money Gram , T/T, Bitcoin Minimum Order Quantity 10g Price Negotiable Usage Antihistaminic, antiemetic, CNS depressant; Stool softener MF

Description

Promethazine is a neuroleptic medication and first-generation antihistamine of the phenothiazine family. The drug has strong sedative and weak antipsychotic effects. It also reduces motion sickness and has antiemetic and anticholinergic properties (via its action on the dopamine receptor D2).

In some countries it is prescribed for insomnia when benzodiazepines are contraindicated. It is available in many countries under many brand names. Promethazine was developed in the mid 1940s when a team of scientists from Rhône-Poulenc laboratories were able to synthesize it from phenothiazine and a diamine side chain of diphenhydramine

Promethazine hydrochloride occurs as a white to faint yellow, practically odorless, crystalline powder which slowly oxidizes and turns blue on prolonged exposure to air. It is soluble in water and freely soluble in alcohol. Each tablet, for oral administration, contains 25 mg or 50 mg of promethazine hydrochloride.

In addition each tablet contains the following inactive ingredients: dibasic calcium phosphate, magnesium stearate, microcrystalline cellulose, sodium starch glycolate and stearic acid. Promethazine Hydrochloride Tablets USP, 50 mg also contain anhydrous lactose.

Medical Uses

Promethazine is used to prevent and treat nausea and vomiting related to certain conditions (such as before/after surgery, motion sickness). It is also used to treat allergy symptoms such as rash, itching, and runny nose.

It may be used to help you feel sleepy/relaxed before and after surgery or to help certain narcotic pain relievers (such as meperidine) work better. It may also be used for a short time to treat a runny nose due to the common cold.

Promethazine is an antihistamine and works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. Its other effects (such as anti-nausea, calming, pain relief) may work by affecting other natural substances (such as acetylcholine) and by acting directly on certain parts of the brain

Perennial and seasonal allergic rhinitis. Vasomotor rhinitis. Allergic conjunctivitis due to inhalant allergens and foods. Mild, uncomplicated allergic skin manifestations of urticaria and angioedema. Amelioration of allergic reactions to blood or plasma. Dermographism.

Anaphylactic reactions, as adjunctive therapy to epinephrine and other standard measures, after the acute manifestations have been controlled. Preoperative, postoperative, or obstetric sedation. Prevention and control of nausea and vomiting associated with certain types of anesthesia and surgery.

Therapy adjunctive to meperidine or other analgesics for control of postoperative pain. Sedation in both children and adults, as well as relief of apprehension and production of light sleep from which the patient can be easily aroused. Active and prophylactic treatment of motion sickness. Antiemetic therapy in postoperative patients.