Pregnenolone CAS NO.: 145-13-1

CAS NO.: 145-13-1

Assay: 99%

Molecular Formula:C21H32O2

Molecular Weight:316.48

Quality Standard: Enterprise Standard

Packing:1kg/foil bag

Appearance: White or almost white crystalline powder

Usage: White crystalline powder. Melting point 193 ℃. Insoluble in water. Use for biochemical studies. Progesterone hormone class medicine intermediate

mp :188-190 °C

alpha :28.5 º (c=1, EtOH)

storage temp. :Refrigerator

Product Categories

Steroids;Steroids&Hormones;Biochemistry;Hydroxyketosteroids;Intermediates&Fine

Chemicals;Pharmaceuticals;Steroid and Hormone;API;chemical reagent;pharmaceutical intermediate;phytochemical;standardized herbal extract

Description

Pregnenolone (3β-hydroxypregn-5-en-20-one), also known as P5, is an endogenous steroid hormone. It is the precursor of the progestogens, mineralocorticoids, glucocorticoids, androgens, and estrogens, as well as the neuroactive steroids. In addition, pregnenolone is biologically active in its own right, acting as a neurosteroid.

Like other steroids, pregnenolone consists of four interconnected cyclic hydrocarbons. It contains ketone and hydroxyl functional groups, two methyl branches, and a double bond at C5, in the B cyclic hydrocarbon ring. Like many steroid hormones, it is hydrophobic. Its esterified version, pregnenolone sulfate, is water-soluble.

Pregnenolone undergoes further steroid metabolism in one of three ways.

Pregnenolone can be converted to progesterone. The critical enzyme step is two-fold using a 3-beta-hydroxysteroid dehydrogenase and a delta 4-5 isomerase. The latter transfers the double bond from C5 to C4 on the A ring. Progesterone is the entry into the delta-4-pathway, resulting in production of 17-hydroxy progesterone and androstenedione, precursor to testosterone and estrone. Aldosterone and corticosteroids are also derived from progesterone or its derivatives.

Pregnenolone can be converted to 17-hydroxy-pregnenolone by the enzyme 17α-hydroxylase (CYP17A1). Using this pathway, termed delta-5 pathway, the next step is conversion to dehydroepiandrosterone (DHEA) using a desmolase.

Pregnenolone can be converted to androsta-5,16-dien-3 beta-ol by 16-ene synthetase.

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