Pregnenolone CAS: 145-13-1

Commonly Used For Pharmaceutical Intermediate Of Progesterone Pregnenolone CAS: 145-13-1

Product Name: Pregnenolone Synonyms: DELTA5-PREGNENOLONE CAS: 145-13-1 MF: C21H32O2 MW: 316.48 EINECS: 205-647-4 mp: 188-190 °C alpha: 28.5 °(c=1, EtOH) storage temp: Refrigerator Description: Pregnenolone and its sulfate, like DHEA and its sulfate and progesterone, belong to the group of neurosteroids that are found in high concentrations in certain areas of the brain, and are synthesized there.

Neurosteroids affect synaptic functioning, are neuroprotective, and enhance myelinization. Pregnenolone and its sulfate ester are under investigation for their potential to improve cognitive and memory functioning. Pregnenolone is also being considered as a potential treatment for schizophrenia.

Interestingly, unlike pregnenolone, pregnenolone sulfate is a negative allosteric modulator of the GABAA receptor as well as a positive allosteric modulator of the NMDA receptor.

In addition, it has been shown to activate the transient receptor potential M3 (TRPM3) ion channel in hepatocytes and pancreatic islets causing calcium entry and subsequent insulin release. Pregnenolone, a molecule produced by the brain, acts as a natural defense mechanism against effects of cannabis/marijuana in animals.

Pregnenolone prevents THC/Tetrahydrocannabinol, the main active principle in cannabis, from fully activating its brain receptor, the CB1 receptor, that when overstimulated by THC/Tetrahydrocannabinol causes the intoxicating effects of cannabis/marijuana.

________________________________ For Your Reference ________________________________ Place of origin : China Certificate : ISO9001:2008, KOSHER, GMP, SGS Quality Standard : USP Minimum Order Quantity : 10 g Production Capacity : 1000 Kg/Month

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