Pharmaceutical Raw Material Norcantharidin

Product Description

Norcantharidin/NCTD/Demethylcantharidin

Norcantharidin Brief Description 1. CAS No.: 5442-12-6; 29745-04-8 MF: C8H8O4;  2. Grade: Food Grade, Medicine Grade 3. Appearance: White Powder 4. Package: 25kg/drum 5. Shelf life:  2 Years 6. Competitive price with high quality 7. Conforms to HPLC 8. Purity: 99%

Norcantharidin Details Norcantharidin (NCTD) has been reported to induce tumor cell apoptosis. However, the underlying mechanism behinds its antitumor effect remains elusive. We have previously shown that TR3 expression is significantly decreased in metastatic melanomas and involved in melanoma cell apoptosis.

In this study, we showed that NCTD inhibited melanoma cell proliferation and induced apoptosis in a dose related manner. NCTD induced translocation of TR3 from nucleus to mitochondria where it co-localized with Bcl-2 in melanoma cells. NCTD also increased cytochome c release from mitochondria to the cytoplasm.

These changes were accompanied by increased expression of Bax and cleaved caspase-3 along with decreased expression of Bcl2 and NF-kappa B2. The effects of NCTD were inhibited by knockdown of TR3 expression using TR3 specific shRNA in melanoma cells.

Furthermore, NCTD significantly decreased tumor volume and improved survival of Tyr::CreER; BRAF(Ca/+); Pten(lox/lox) transgenic mice. Our data indicates that NCTD inhibits melanoma growth by inducing tumor cell apoptosis via activation of a TR3 dependent pathway. These results suggest that NCTD is a potential therapeutic agent for melanoma. 

Norcantharidin COA Product Name Norcantharidin Powder Part Used Shell CAS NO. 5442-12-6 Botanical Source Mylabris Phalerata Pallas Appearance White Powder Test Method HPLC Specification Norcantharidin 99% Loss on drying