Paclitaxel

Paclitaxel

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CAS: 33069-62-4

MF: C47H51NO14

MW: 853.91

EINECS: 205-285-7

mp 213 °C (dec.)(lit.)

refractive index -49 ° (C=1, MeOH)

storage temp. 2-8°C solubility methanol: 50 mg/mL, clear, colorless

form powder

color white Stability: Stable. Incompatible with strong oxidizing agents. Combustible.

Chemical Properties White Powder

Usage glucocorticoid, antiinflammatory

Usage An antineoplastic. Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanc ed forms of Kaposi's sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy.

General Description Needles (from aqueous methanol) or fine white powder. An anti-cancer drug.

Air & Water Reactions May be sensitive to prolonged exposure to moisture. .

Health Hazard TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard Flash point data for Paclitaxel are not available. Paclitaxel is probably combustible.

Biological Activity Antitumor agent; promotes and stabilizes tubulin polymerization, causing cell cycle arrest. Induces autocatalytic activation of caspase-10 in CCRF-HSB-2 cells, triggering apoptosis.

Synonyms: N-BENZYL-BETA-PHENYLISOSERINE ESTER;PACLITAXEL, TAXUS BREVIFOLIA;PACLITAXEL, TAXUS SPECIES;PACLITAXOL;PACLITAXEL;TAXOL(TM);taxol a;TAXOL EQUIVALENT

Product Categories: Active Pharmaceutical Ingredients;Pharmaceutical material and intermeidates;Antineoplastics;Antineoplastic;APIs;Antitumors for Research and Experimental Use;Biochemistry;Natural Plant Extract;Intermediates & Fine Chemicals;Pharmaceuticals;Natural Anti-cancer Medical Materials and It's Derivatives;Antitumour;Signalling;Aromatics;Chiral Reagents;Heterocycles;Plant extract;API;Plant extracts;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;CLOBEX;Isolabel;antibiotic;Anti-cancer&immunity