Nebivolol hydrochloride
Specifications
- Origin
- hubei china
- Packaging
- Drum/foil bag
- Price Term
- EXW/EX-Work,FOB
- Payment Term
- T/T,L/C,Western Union
Nebivolol hydrochloride is a Chemicals product. Key specs — Origin: hubei china; Packaging: Drum/foil bag; Price Term: EXW/EX-Work,FOB; Payment Term: T/T,L/C,Western Union.
Product Description
Nebivolol hydrochloride
Synonyms: RAC NEBIVOLOL, HYDROCHLORIDE;a,a(Iminodimethylene)bis[6-fluoro-2-chromanmethanol] Hydrochloride;Lobivon;Nebilet;Nebilox;R-67555;NEBIVOLOLHYDROCHLORIDE(SUBJECTTOPATENTFREE);a,a'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol hydrochloride CAS: 152520-56-4 MF: C22H26ClF2NO4 MW: 441.9
Chemical Properties White to Off-White Powder Usage A ?-Adrenergic blocker.
Used as an antihypertensive Usage Nebivolol selectively inhibits β1-adrenoceptor with IC50 of 0.8 nM Biological Activity Highly selective β 1 -adrenoceptor antagonist (K i values are 0.88, 20, 44, 700, 1160, 2400 and 4000 nM at β 1 , 5-HT 1A , β 2 , 5-HT 2 , α 1 , H 1 and D 2 receptors respectively).
Induces vasodilation via a nitric oxide- and cGMP-dependent mechanism (EC 50 = 11.36 μ M in renal arteries) and displays antihypertensive activity in vivo .
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