Methotrexate

Methotrexate

Synonyms: METHOTREXATE;METHYLAMINOPTERIN;METHYLAMINOPTERINE;ANTIFOLAN;L-(+)-AMETHOPTERIN;4-AMINO-N 10-METHYLPTEROYL-L-GLUTAMIC ACID;4-AMINO-10-METHYLPTEROYLGLUTAMIC ACID;(+)-4-AMINO-10-METHYLFOLIC ACID CAS: 59-05-2 MF: C20H22N8O5 MW: 454.44 EINECS: 200-413-8

Chemical Properties Yellow Crystaline Powder Usage A Folic acid antagonist. Used as a antineoplastic and antirheumatic. Usage Anti-cancer Usage dietary supplement, crosses the blood-brain barrier, potential activities as anxiolytic and vasodilator Usage Used as a antineoplastic and antirheumatic.

A folic Acid antagonist General Description Odorless yellow to orange-brown crystalline powder. Air & Water Reactions Methotrexate is sensitive to hydrolysis, oxidation and light. Insoluble in water. Reactivity Profile Methotrexate decomposes in very acidic or alkaline conditions. Methotrexate is incompatible with strong oxidizing agents and strong acids.

Fire Hazard Flash point data for Methotrexate are not available; however, Methotrexate is probably combustible. Biological Activity Cytotoxic agent. Inhibits thymidylate synthetase and de novo purine synthesis. Potent folic acid antagonist; inhibits dihydrofolate reductase.

Also inhibits Ras carboxyl methylation in DKOB8 cells, leading to decreased p44 and Akt activation.