Human soluble CD40 ELISA kit

Product Name

Human soluble CD40 ELISA kit Product Type : ELISA Kit

Code : CSB-E15854h

Size : 96T,5×96T,10×96T

Uniprot NO. : P25942

Alias : Bp50, CDW40, MGC9013, TNFRSF5, p50, B cell surface antigen CD40|B cell-associated molecule|CD40 antigen|CD40 antigen (TNF receptor superfamily member 5)|CD40 type II isoform|CD40L receptor|nerve gro

Species : Human

Sample Types : serum, plasma, tissue homogenates

Detect Range : 62.5 pg/ml-4000 pg/ml

Sensitivity : 15.6 pg/ml

Assay Time : 1-5h

Sample Volume : 50-100ul

Detection Wavelengt : 450 nm

Availability : 3-5 working days

Research Area : Others

Protocol

Instructions

Protocol may be improved. Please feel free to contact CUSABIO product specialist to obtain the latest version.

Target details : This protein is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.