Gamma linolenic Acid

Gamma linolenic Acid

Another Name:

CAS:

Molecular Weight:278.4296

Molecular Formula:C18H30O2

At present, the domestic production of gamma-linolenic acid is mainly derived from evening primrose.

This plant is native to North America, northeast China, wild, in recent years the country has a large area of artificial cultivation, the Jilin Yanbian region only acreage in 1988 2O00 hectares. γ-linolenic acid can also be mass-produced by microbial fermentation method.

This product is the precursor of the structure of the material composition of human tissues and biofilms, is also a synthetic prostaglandin. As the human body is essential unsaturated fatty acids, the adult daily requirement of about 36mg/kg.

Such as inadequate intake can lead to disorders of function in the body caused by certain diseases, such as diabetes, high blood cholesterol.

Edit this paragraph the role of nutrition and health of the γ-linolenic acid, anti-cardiovascular disease effect Thromboxane A2 (TXA2) is the most intense endogenous platelet aggregation agent and a vasoconstrictor, and prostacyclin (PGI2) as the most strong vasodilator.

Normal body to maintain a balance between the two, in order to maintain a platelet physiological role.

Once TXA2 synthesis increased, PGI2 decreased production, increased platelet aggregation caused by blood clots. γ-linolenic acid the antithrombotic cardiovascular mechanism: (1) GLA inhibit platelet aggregation; (2) GLA converted into DHA, γ-linolenic acid inhibits platelet TXA2 synthetase activity as a precursor of the PGE1.

Has a mitigating effect of thrombosis, γ-linolenic acid, may reduce the risk of cardiovascular and cerebrovascular diseases caused by thrombotic, it also can inhibit the formation of atherosclerotic shaped sclerosis, protection of the ischemic myocardium, reduce necrotic area, to maintain the normal function of platelets.

2, the lipid-lowering effects γ-linolenic acid can be reduced as the precursor of the PGE1 in the total cholesterol, γ-linolenic acid can increase the polarity of cholesterol and water soluble, and to make it susceptible to enzymatic hydrolysis, can also be cleared from the blood triglycerides, reduced endogenous cholesterol synthesis, thereby reducing the generation of the β-lipoprotein.

Therefore, γ-linolenic acid can reduce total cholesterol in the blood, has played the role of lipid-lowering. γ-linolenic acid treatment of hyperlipidemia reported better efficacy, drug safety.

3 hypoglycemic effect The phospholipid composition by the γ-linolenic acid can enhance the fluidity of the membrane phospholipid, and enhance the sensitivity of membrane receptors for hormones (including insulin). By the γ-linolenic acid from the prostaglandin and other active substances, can improve the function of pancreatic β-cells to secrete insulin.

The γ-linolenic acid as the polyunsaturated fatty acids can also help restore the diabetic human cell fatty acid desaturase activity. 4, anti-cancer effect γ-linolenic acid can be used as a potential anti-cancer drugs.

Studies have shown that gamma-linolenic acid, it has a significant role Lipid oxidation, γ-linolenic acid is first oxidized in the body, thereby reducing lipid peroxidation damage. Studies have shown that gamma-linolenic acid can inhibit human hepatoma cell growth.

The inhibition of human colon cancer, gastric cancer and pancreatic cancer cell DNA synthesis, γ-linolenic plus Fe (II), significant effects of the treatment of breast cancer.

5, whitening and anti-skin aging effects generated by the reaction of γ-linolenic acid and kojic of kojic single γ-linolenate can be used as an inhibitor of tyrosinase, with the role of anti-melanin, the ointment can be used as a whitening cosmetic functional factors can also be made pigmentation., Γ-linolenic acid can be used as natural oils raw materials for cosmetics, and protect the skin, moist skin, slow down skin aging, as well as the treatment of chronic eczema, promote blood circulation.

Therefore, γ-linolenic acid as a food additive or nutritional supplement, long-term consumption can improve the structure of the human food, strengthens the immune system, thus it together, known as "the protagonist of the 21st century functional foods and other polyunsaturated fatty acids.

Infants and young children, the elderly, and cause metabolic disorders in adults due to obesity, disease or excessive drinking, mineral elements or insufficient intake of vitamin should complement γ-linolenic acid.

Some foreign pharmaceutical or food companies, in order to meet the requirements of specific consumer groups, has been developed for the elderly and children production of γ-linolenic acid-containing food such as: milk, powdered milk, juice, beverage, jelly, biscuits, chocolate, chewing gum and so on. Γ-linolenic acid in recent years, the medical community is very active clinical research also found that γ-linolenic acid on obesity, schizophrenia, women's menstrual syndrome, cyclical breast pain, as well as a variety of inflammation (rheumatoid arthritis, ulcers Festival enteritis, nephritis, etc.) and also has a good role in the improvement, which indicates that γ-linolenic acid has a broader application prospects.

In general, we have more from the food intake of linoleic acid into gamma-linolenic acid, the body to maintain normal functioning of the role of the enzyme in the body, and a series of biosynthetic role.

When excessive intake of saturated fatty acids or other metabolic disorders, will affect the conversion of linoleic acid to gamma-linolenic acid, thus affecting the normal functioning of the body, resulting in the generation of various diseases.

Therefore, if timely replenishment of gamma-linolenic acid, can promote the metabolism of the body function normally, thereby reducing the occurrence of disease.

Experimental and clinical studies have shown that, This product has significant anti-lipid peroxidation, lower total cholesterol, and increase high-density lipoprotein cholesterol, inhibit platelet aggregation and thromboxane A2 synthesis, lower blood pressure, inhibit ulcers and stomach bleeding, increased insulin secretion, weight loss and so on.

For certain age-related diseases such as diabetes, high cholesterol disease, atherosclerosis, thrombotic cardiovascular and cerebrovascular diseases, cancer and gastric ulcers, obesity, schizophrenia, clinical, atopic eczema, rheumatoid arthritis, vasculitis, etc.