Estradiol valerate CAS:979-32-8

CAS:979-32-8

MF: C23H32O3

MW: 356.5

Purity: 99%

Appearance: White fine powder

Density: 1.13g/cm3

Boiling Point: 486.2° C at760mmHg

Melting Point: 144º C

Flash Point: 191.1° C

Refractive index: 1.567

Packing:5kg/drum

25kg/drum

Description

Estrogens direct the development of the female genotype in embryogenesis and at puberty. Estradiol is the major estrogen secreted by the premenopausal ovary. Estradiol benzoate is an estradiol analog which contains a benzyl ester at the C-3 position and is often used in combination with a progestin to induce estrus in domestic livestock. This compound binds to the human and murine estrogen receptor α (ERα), and chicken ER with IC50 values in the range of 22-28 nM. This reflects a 6-10 fold reduction in binding affinity compared to estradiol.

Application

Upon ingestion, regardless of the route of administration, estradiol valerate behaves as a prodrug, being cleaved by esterases in blood plasma and the liver into 17β -estradiol and valeric acid. However, compared to estradiol itself, estradiol valerate is absorbed more slowly and possesses a longer duration, especially when given in an oil solution via intramuscular injection (in which it acts as a depot). As a result, it can be administered less frequently

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