Cyclosporin A

Cyclosporin A CYCLOSPORINE

Synonyms: ol27-400;s7481f1;sandimmun;sandimmune;ANTIBIOTIC S 7481F1;ANTIBIOTIC S 7481FI;CICLOSPORIN;CICLOSPORIN A CAS: 59865-13-3,79217-60-0 MF: C62H111N11O12 MW: 1202.61

Chemical Properties White Powder Usage prothrombogenic agent Usage Cyclosporin A is a hydrophobic cyclic peptide isolated from several fungal species including Cylindrocarpon, Fusarium, Trichoderma and Tolypocladium. Cyclosporin A inhibits T-cell activation and has been marketed since 1983 as an immunosuppressant in post-allogeneic organ transplant.

Cyclosporin A acts by binding to the protein, cyclophilin (immunophilin), in T-lymphocytes causing inhibition of calcineurin (protein phosphatase 2B). Cyclosporin A reduces transcription of interleukin 2, and inhibits lymphokine production, interleukin release and NO synthesis induced by interleukin 1α, lipopolysaccharides and TNFα.

Usage An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. A group of nonpolar cyclic oligopeptides with immunosupppressant activity. General Description White prismatic needles (from acetone) or white powder. Air & Water Reactions Slightly water soluble .