Bifidobacterium longum lysate

Bifidobacterium longum lysate

CAS:96507-89-0 EINECS:306-168-4

Probiotic health benefits As an important organism involved in the maintenance of the human gastrointestinal tract, B. longum is commonly used as a probiotic in various dairy products.Its presence has been associated with many health benefits including improving lactose tolerance and preventing diarrhea, food allergies, and colonization by pathogens.Some strains of B. longum were demonstrated to have an antioxidative effect by inhibiting linoleic acid peroxidation,a process that results in the creation of lipid hydroperoxides that decompose into highly reactive radicals associated with aging and age-related diseases.Additionally, B. longum can scavenge free radicals, lowering a person’s chance of atherosclerosis and stroke.The ability of B. longum to remove cholesterol from its environment by incorporating cholesterol into its membrane is thought to lower the serum cholesterol level in humans.

B. longum may also bind and suppress resorption of bile acids,which also lowers serum cholesterol levels as bile salt replacement requires utilization of cholesterol within the body.B. longum supplementation was shown to significantly suppress tumor volume and incidence, although the exact mechanism is not clear.

Since high colonic pH is thought to promote colorectal cancer, it is postulated that B. longum can inhibit colorectal cancer by producing bile acid and cholesterol metabolites that lower the intestinal pH.

Therapeutic uses Cancer treatment As an anaerobe, B. longum is able to localize and proliferate in the hypoxic regions of solid tumors when injected intravenously.It is proposed that by introducing genes into B. longum that generate anti-tumor enzymes, B. longum will be able to act as the vector in cancer gene therapy.B. longum is an ideal vector as its actions should remain tumor-specific, it is non-pathogenic, and it generally easily killed by antibiotics unlike other potential anaerobic vectors such as Salmonella or Clostridium.