Aripiprazole

Quick Details Name: Aripiprazole

Synonym: ARIPIPRAZOLE;ARIPIPRAZOLE-D8;ABILIFY;ABILITAT;7-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydrocarbostyril;OPC 14597;OPC 31;7-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-2(1H)-quinolinone

CAS: 129722-12-9

MF: C23H27Cl2N3O2

MW: 448.39

Assay: 99%

Main components: 7- [4- [4- (2,3-dichlorophenyl) -1-piperazinyl] butoxy] -3,4-dihydro-quinolinone

Nature : colorless flaky crystals

MP 139.0 ~ 139.5 ℃. Package: 10kg/drum

Standard: enterprise Standard

MOQ: 1kg

Method : 7- (4-bromo-butoxy) -3 4 dihydrocarbostyril and sodium iodide in acetonitrile reflux. 1- (2 3-dichlorophenyl) piperazine and triethylamine reflux. The solvent was distilled off, and the resulting material was dissolved in chloroform, washed with water, dried over anhydrous magnesium sulfate. Recrystallized from ethanol can be.

Description Aripiprazole (AIR-i-PIP-r-zohl; brand names: Abilify, Aripiprex) is an atypical antipsychotic. It is primarily used in the treatment of schizophrenia, bipolar disorder, major depressive disorder (as an add on to other treatment), tic disorders, and irritability associated with autism.

It was approved by the U.S. Food and Drug Administration (FDA) for schizophrenia on November 15, 2002 and the European Medicines Agency on 4 June 2004; for acute manic and mixed episodes associated with bipolar disorder on October 1, 2004; as an adjunct for major depressive disorder on November 20, 2007; and to treat irritability in children with autism on 20 November 2009. Likewise it was approved for use as a treatment for schizophrenia by the TGA of Australia in May 2003. It is a partial dopamine agonist.

Aripiprazole was developed by Otsuka in Japan, and in the United States, Otsuka America markets it jointly with Bristol-Myers Squibb

Applications

US Food and Drug Administration (FDA) approved the listing on November 15, 2002. Quinoline derivatives, is the third generation of atypical antipsychotics. Aripiprazole is the first dopamine system stabilizer, have a significant effect on the positive and negative symptoms of schizophrenia. For the treatment of schizophrenia, can significantly improve the kind of schizophrenic symptoms, but no other antipsychotics some common side effects such as weight gain and involuntary muscle activity, etc., but may cause headaches, anxiety and insomnia symptoms.

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