Alprostadil

Alprostadil product Name Prostaglandin E1 Molecular Formula C20H33O5 Molecular Weight 353.4736 CAS Registry Number 745-65-3 EINECS 212-017-2 Molecular Structure Melting point 115-116℃ Boiling point 529.282°C at 760 mmHg Flash point 287.975°C Water solubility insoluble Vapour Pressur 0mmHg at 25°C InChI InChI=1/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 Synonyms ALPROSTADIL; Prostaglandin E1 or AIPROSTADIL; Alprostadil (prostandin E1); 11,15-dihydroxy-9-oxoprost-13-en-1-oic acid; (11alpha,15S)-11,15-dihydroxy-9-oxoprost-13-en-1-oic acid; (11alpha,12xi,13E,15S)-11,15-dihydroxy-9-oxoprost-13-en-1-oic acid; (11alpha,13E,15S)-11,15-dihydroxy-9-oxoprost-13-en-1-oate

Prostaglandin E1 Chemical Properties alpha -64 º (c=1.0, C2H5OH) storage temp. −20°C solubility ethanol: 1 mg/mL Chemical Properties Crystalline Solid Water Solubility insoluble

Usage A primary Prostaglandin; easily crystallized from purified biological extracts. Vasodilator (peripheral) Usage Vasodilator;Prostaglandin receptor agonist Biological Activity Prostaglandin with some selectivity for EP 3 and EP 4 receptors (K i values are 1.1, 2.1, 36, 10? and 33 nM for mouse EP 3 , EP 4 , EP 1 , EP 2 and IP receptors respectively). Inhibits platelet aggregation and is a vasodilator in vivo .